Spain maintained their 100% record at Euro 2008 thanks to a 2-1 victory over Greece, to send the defending champions home with no points.
Dani Guiza and Ruben de la Red scored second-half goals as Spain came back from a 1-0 half-tine deficit following Angelos Charisteas’ opener for Greece.
With a quarter-final encounter with World Champions Italy on the horizon, Spanish coach Luis Aragones made ten changes from the side that beat Sweden.
The changes ensured a fairly low-key game played at a leisurely pace, although Greece woke the crowd from their slumber when they went ahead shortly before half-time.
Karagounis, who had earlier made history by becoming the first player to collect six yellow cards at the European Championships, swung in a free-kick that picked out Charisteas and the forward headed powerfully past Pepe Reina.
Liverpool midfielder Xabi Alonso almost caught out Antonis Nikopolidis with a shot from inside his half that just landed the wrong side of the post and led to Greece’s keeper crashing into the post.
The upright denied a lobg range effort from Alonso as Spain began to assert themselves after the break.
Theyeventually equalised when De la Red pounced on a Guiza knockdown and hammered in a shot off the underside of the bar.
Charisteas hit the outside of the post for Greece, but Spain had the final word when Sergie Garcia set up Guiza to head homefrom close range in the dying stages.
Greece 1-2 Spain
Greece: Angelos Haristeas 42
Spain: Ruben de la Red 61, Daniel Guiza 88
Greece: 1-Antonis Nikopolidis; 11-Loukas Vintra, 16-Sotiris Kyrgiakos (19-Paraskevas Antzas 62), 5-Traianos Dellas, 4-Nikos Spyropoulos; 6-Angelos Basinas, 21-Costas Katsouranis, 14-Dimitris Salpigidis (8-Stelios Giannakopoulos 86), 10-Giorgios Karagounis (22-Alexandros Tziolis 73), 20-Yannis Amanatidis; 9-Angelos Haristeas
Spain: 23-Pepe Reina; 18-Alvaro Arbeloa, 20-Juanito, 2-Raul Albiol, 3-Fernando Navarro; 14-Xabi Alonso; 22-Ruben de la Red, 10-Cesc Fabregas, 16-Sergio Garcia, 6-Andres Iniesta (12-Santi Cazorla 58); 17-Daniel Guiza
Referee: Howard Webb (England)