Italy sneak a draw against impressive Spain, while new boys Kosovo have a home debut to forget.
Having slipped to seventh in the race to reach Russia, Chile may be forced to go call up a player whose international career appeared to be over.
In a highly competitive CONMEBOL qualifying group, Chile's Golden Generation cannot afford to drop too many more points.
A testing World Cup qualifier in the rarefied heights of Quito will provide a tough baptism for new Brazil coach Tite.
Four new international coaches and the return of Lionel Messi coincide with the return of the World Cup qualifiers.
Vitaly Mutko has been implicated in Russia's doping scandal - which is bad news for him and bad news for Fifa.
Russian sports minister promises safe, secure experience for fans at 2018 World Cup.
Tim Vickery explains why the South American World Cup qualification benefits all countries of the region.
Brian Glanville lambasts Uefa for their failure to spot the potential for trouble in Marseille.
Five years to the day since Russia and Qatare were named the World Cup hosts, FA chief says it was Fifa's worst moment.