Champions League holders Barcelona have been drawn to face 2005 winnners Liverpool in the last 16 of this season’s competition.
The first leg will be played at the Nou Camp with Liverpool hosting the return leg at Anfield a fortnight later.
Barcelona director Josep Cubells said: “It’s an interesting match to play Liverpool the champions of Europe the year before.
“Both are legendary clubs with very glamorous stadiums and enthusiastic supporters.”
Jose Mourinho will return to Porto, where he won the trophy in 2004, with Chelsea, while Manchester United will be pleased with their draw against French side Lille.
Milan, perennial favourites to win the competition, face Scottish champions Celtic, while while last season’s runners-up Arsenal play PSV Eindhoven.
Arsenal vice-chairman David Dein was happy with the draw and is looking forward to his team going one better than last season.
He said: “PSV have done very well, and it will not be easy. But it was the same last year – at this stage of the competition they are all good teams.
“We want to win the Champions League and we came very close last season. This time we want to go one better.
“This is a competition we have never won before – and we are determined to win it.”
Two former winners, Real Madrid and Bayern Munich, will meet for a place in the last eight, while French champions and dark horses Lyon will face Roma. In the other tie, Serie A leaders Inter play Spanish side Valencia.
Porto v Chelsea
Celtic v Milan
PSV Eindhoven v Arsenal
Lille v Manchester United
Roma v Lyon
Barcelona v Liverpool
Real Madrid v Bayern Munich
Inter Milan v Valencia
Ties to be played on 21/22 February and 6/7 March