Lille coach Claude Puel hopes that playing home Champions League matches at the Stade de France will bring the best out of his team.
They are being forced to play in Paris because their own ground us currently undergoing renovations.
“There’s no question the Stade de France is a wonderful arena,” Puel said.
“The most important thing is that we feel at home as quickly as possible, otherwise it’ll be like playing six away games.”
After losing 1-0 at Benfica a fortnight ago, Lille cannot afford a second defeat. Puel may go for a more attacking line-up than usual by pairing in-form forwards Moussilou and Peter Odemwingie.
“We don’t have to win at any cost, but we want to announce ourselves in this competition and we’ll try hard to get the three points,” Puel said.
Defender Milivoje Vitakic is missing through suspension, but Lille are otherwise at full strength.
Villarreal have begun their domestic season slowly and they were lying bottom Saturday’s 2-1 victory at Espanyol.
Coach Manuel Luis Pellegrini admitted that result came as a relief.
“It was important because we were being put under pressure by the Spanish media,” he said.
“Now we can focus on the Lille game with clear heads.”
Pellegrini disagreed with suggestions that Lille were the weakest team in the group.
“They are very well-organised, they keep possession well and they have very fast strikers,” he said. “For me the group is evenly balanced, even if United are perhaps slightly stronger than the rest.”
Argentina playmaker Juan Román Riquelme is back after missing the United match through injury, while Dutch defender Jan Kromkamp should recover from a bout of flu.