Holders Manchester United and runaway Premiership leaders Chelsea both face difficult away ties against Premiership opposition in the FA Cup fifth round.
United were drawn against fourth-placed Everton, while Chelsea face a trip to Newcastle.
The tie between Manchester United and Everton could see the return of teenage striker Wayne Rooney to his former club for the first time since his £27m move in August.
FA Cup 5th round draw:
Bolton Wanderers v Derby County or Fulham
West Bromwich Albion or Tottenham Hotspur v Nottingham Forest
Everton v Manchester United
Charlton Athletic v Leicester City (II) Burnley (II) v Blackburn Rovers
Southampton v Brentford (III) or Hartlepool United (III)
Newcastle United v Chelsea
Arsenal v West Ham United (II) or Sheffield United (II)
Ties to be played weekend of February 19 and 20.