Ruud van Nistelrooy will miss Manchester United’s Champions League clash against Fenerbahce on Wednesday.

Van Nistelrooy picked up a calf injury which forced him to sit out Saturday’s 3-0 win over Southampton.

Manager Sir Alex Ferguson said: “Ruud has this injury at the bottom of his calf and it is proving troublesome.

“We felt we had to leave him out against Southampton and Fenerbahce to try and get him back 100%.”

“We’ll rest a few of Saturday’s team,” added Ferguson.

“The boys who played in the Carling Cup against Arsenal on Wednesday will get a chance.”