Although third place has not yet been mathematically secured, Costa Rica need just a point against the United States to secure their finals berth.
The fourth and final place, which earns a play-off against Bahrain or Uzbekistan for a place at the World Cup rests between Trinidad & Tobago and Guatemala.
The US and Mexico have already secured final berths.
Fixtures
Group
Panama v Trinidad/Tobago
Mexico v Guatemala
Costa Rica v USA