Holders Internazionale will continue their Champions League defence against Bayern Munich after the round of 16 draw was made in Nyon, Switzerland in a repeat of last season’s final.
Rafael Benítez’s side finished second in Group A and have been drawn to meet the Group E winners Bayern, whom they beat 2-0 in Madrid seven months ago.
There will also be a rematch of the 2006 final as Barcelona were again paired with Arsenal, who they eliminated in last season’s quarter-finals.
Real Madrid, who have lost in the last 16 for six successive seasons, take on the side who eliminated them from the 2009-10 competition, Lyon – the French side having reached the semi-finals for the first time last term.
Seven-time European champions Milan will face Tottenham Hotspur while French titleholders Marseille will meet Manchester United, winners in 2008 and finalists the following year.
Valencia, runners-up in 2000 and 2001, take on Schalke and Chelsea face FC Copenhagen, the first Danish team to progress from the group stage. In the round’s other game, Shakhtar Donetsk, also making their maiden appearance in the round of 16, will play Roma.
Champions League last 16 draw
Roma v Shakhtar Donetsk
Milan v Tottenham
Valencia v Schalke
Inter v Bayern Munich
Lyon v Real Madrid
Arsenal v Barcelona
Marseille v Manchester United
Copenhagen v Chelsea
First legs to be played on 15/16 and 22/23 February
Second legs to be played on 8/9 and 15/16 March