Bolton midfielder Stuart Holden will be out of action for six weeks after suffering a fracture to his right leg.
Holden picked up the injury during the United States’ 2-1 friendly defeat by Holland on Wednesday.
The 22-year-old, who joined Wanderers in January, has started Bolton’s last two matches.
And Bolton boss Owen Coyle told the club website: “In both games we saw his quality so it’s a blow, the important thing is he returns bigger and better.”
Coyle is also hopeful the injury will not harm Holden’s prospects of playing in the World Cup.
“We’re erring on the side of six weeks, and if that is the case then he will be capable of playing the last part of the season for us and putting himself in the frame for the World Cup,” said Coyle.
“We’ve already spoken with him and his representative to assure him he will be here for longer because of the belief I have in him, and the quality he has shown since he came to the club.”