Serie A sides Juventus, Lazio and Fiorentina have been demoted to the Serie B for their involvement in the match-fixing scandal which has enguled Italian football in recent months.
Juventus were also stripped of their last two Serie A titles and had 30 points deducted.
Milan will stay in Serie A but will start the season docked 15 points.
Lazio were deducted seven league points while Fiorentina suffered a 12-point penalty.
All are barred from competing in Europe – Juventus, Milan and Fiorentina the Champions League; Lazio the Uefa Cup.
Juventus president Giovanni Cobolli Gigli said: “This verdict is unheard of. We expected a balanced sentence not only in form but in substance, our expectations were different ones.
“We could have expected relegation to the second division but to be also handed a 30-point deduction is almost like relegation to the third division. We will appeal.”
A statement on Fiorentina’s official site read: “Fiorentina wishes to reiterate the absolute correctness of the club and of their own executives.
“Fiorentina will fight with every means possible so that the truth of the facts are revealed.”
An Milan statement said: “Milan retains the decision by the CAF of extraordinary injustice.
“We will appeal once the documents of the verdict will be available, with the certainty that the procedure will be radically modified by appeal.”
Inter, Roma, Chievo and Palermo, who finished third, fifth and seventh and eighth are in line to take the places of the penalised clubs in next season’s Champions League, provided the verdicts are upheld after the expected appeals.
Lecce, Messina, and Treviso will avoid relegation to Serie B and keep their places in the top flight.